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Karlsruhe Institute of Technology

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76131 Karlsruhe

 

Tel. +49 721 608-46184

E-Mail: infoIlf7∂yin kit edu

 

Das KIT ist seit 2010 als familiengerechte Hochschule zertifiziert.
Dr. Pavel Levkin

Dr. Pavel Levkin

Group Leader at ITG
Functional and Stimuli-Responsive Polymer Materials
Group: Helmholtz
Room: Deutschland, KIT
Phone: +49 721 608-29175
Fax: +49 721 608-23354
levkinVek9∂kit edu


Karlsruhe Institute of Technology (KIT)

Postfach 3640

76021 Karlsruhe

Fon: +49-721 608-29175

Fax: +49-721 608-23354

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Junior Research Group of Dr. Pavel Levkin

Nachwuchsgruppe Dr. Pavel Levkin

Alexander Efremov, Junsheng Li, Linxian Li, Barbara Kwiatkowska, Florian Geyer, Viktoria Nedashkivska, Erica Ueda, Dr. Pavel Levkin, David Zahner

Functional and Stimuli-Responsive Polymer Materials

Junior Research Group of Dr. Pavel Levkin

 

The goal of our research is to gain better understanding of biological interfaces and to advance our ability to effectively control and direct behavior of eukaryotic cells and bacteria. We are developing biologically active functional polymer surfaces and materials, "smart" switchable polymer surfaces, and gradient surfaces, which we use for investigation of biointerfaces, for studying cell- or bacteria-surface interactions, for studying biofouling and for creating "smart" culture devices. Our motivation is to create polymer films and coatings that will improve performance of existing biomedical devices, implants and cell culture dishes. Our research is very interdisciplinary and we closely collaborate with biologists, microbiologists and physicists.
 

Publications

Junior Research Group of Dr. Pavel Levkin

PATENTS

  • Superhydrophobic and superhydrophilic materials, surfaces and methods. P.A. Levkin, F. Svec, J.M.J. Fréchet. WO/2009/137267; PCT/US2009/041277 (International patent)

PUBLICATIONS

  • Visible light initiated polymerization of styrenic monolithic stationary phases using 470 nm    light emitting diode arrays. Z. Walsh, P.A. Levkin, V. Jain, B. Paull, F. Svec, and M. Macka J. Sep. Sci. accepted
  • Porous polymer coatings: a versatile approach to superhydrophobic surfaces
    P.A. Levkin, F. Svec, J.M.J. Fréchet
    Adv. Funct. Mater. 19 (2009), 1993-1998
  • Monolithic porous polymer stationary phases in polyimide chip for fast HPLC separation of proteins
    P.A. Levkin, S. Eeltink, T.R. Stratton, R. Brennen, K. Killeen, F. Svec, J.M.J. Fréchet
    Journal of Chromatography A 1200 (2008), 55-61
  • Apparent and true enantioselectivity of single- and binary-selector chiral stationary phases in gas chromatography
    P.A. Levkin and V. Schurig
    Journal of Chromatography A (invited paper in 50th anniversary issue) 1184 (2008), 309-322
  • Heptakis[6-O-(n-acetylyl-L-valine-tert-butylamide)-2,3-di-O-methyl]- b-cyclodextrin: a new multifunctional cyclodextrin with improved enantiodiscriminating efficiency towards polar and apolar substrates
    G. Uccello-Barretta, S. Nazzi, F. Balzano, P.A. Levkin, V. Schurig, P. Salvadori
    European Journal of Organic Chemistry (2007), 3219-3226
  • Sterically hindered and completely arrested nitrogen inversion in pyrazolidines
    S.V. Usachev, G.A. Nikiforov, K.A. Lyssenko, Y.V. Nelubina, P.A. Levkin, R.G. Kostyanovsky
    Tetrahedron-Asymmetry 18 (2007), 1540-1547
  • Temperature-induced reversal of elution order of enantiomers in gas chromatography: N-ethoxycarbonyl propyl amides and N-trifluoroacetyl ethyl esters of a-amino acids on Chirasil-Val and Chirasil- b-Dex CSP
    P.A. Levkin, A. Levkina, H. Czesla and V. Schurig
    Analytical Chemistry, 79 (2007), 4401-4409
  • Expanding the enantioselectivity of the gas-chromatographic chiral stationary phase Chirasil-Val-C11 by doping it with octakis(3-O-butanoyl-2,6-di-O-n-pentyl)- g-cyclodextrin
    P.A. Levkin, A. Levkina, H. Czesla, S. Nazzi, V. Schurig
    Journal of Separation Science, 30, (2007), 98-103
  • Combining the enantioselectivities of L-valine diamide and permethylated
     
    b-cyclodextrin in one gas chromatographic chiral stationary phase
    P.A. Levkin, A. Levkina, V. Schurig
    Analytical Chemistry, 78 (2006), 5143-5148
  • Combining the enantioselectivity of a cyclodextrin and a diamide selector in a mixed binary gas-chromatographic chiral stationary phase
    P.A. Levkin, A. Ruderisch, V. Schurig
    Chirality, 18 (2006), 49-63
  • Absolute configuration of Troeger bases: an X-ray diffraction and circular dichroism study
    D.A. Lenev, K.A. Lyssenko, D.G. Golovanov, O.R. Malyshev, P.A. Levkin, R.G. Kostyanovsky
    Tetrahedron Letters, 47 (2006), 319-321
  • Solid-state ESR differentiation between racemate vs. enantiomer
    P.A. Levkin, A. I. Kokorin, V. Schurig, R. G. Kostyanovsky
    Chirality, 18 (2006) 232-238
  • Solid-phase racemic compound-conglomerate transformation of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-dione
    P.A. Levkin, E. Schweda, H.-J. Kolb, V. Schurig, R.G. Kostyanovsky
    Tetrahedr. Asymm., 15 (2004) 1445-1450
  • Temperature-dependent racemic-compound-conglomerate crystallization of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-dione
    P. A. Levkin, Y. A. Strelenko, K. A. Lyssenko, V. Schurig, R. G. Kostyanovsky
    Tetrahedr. Asymm., 14 (2003) 2059-2066
  • A new conglomerate in a series of 2,3:6,7-dibenzobicyclo[3.3.1]nonanes
    P. A. Levkin, K. A. Lyssenko, V. Schurig, R. G. Kostyanovsky
    Mendeleev Commun., 13 (2003) 106-108
  • Ångström-sized pore crystal
    R. G. Kostyanovsky, P. A. Levkin, K. A. Lyssenko, Yu. A. Strelenko, D. G. Golovanov
    Mendeleev Commun., 12 (2002) 220-222

    BOOK CONTRIBUTIONS

    “Homo- and heterochirality in crystals“ in Topics in Stereochemistry
    P.A. Levkin, V.Yu. Torbeev, D.A. Lenev, R.G. Kostyanovsky
    Ed.: F. Toda, John Wiley & Sons Ltd, 25 (2006), 81-134

    PRESENTATIONS (oral and poster)

     
  • Use of light emitting diodes in the visible region to initiate polymerisation leading to monolithic stationary phases (poster) Z. Walsh, D. Heger, S. Abele, P. Klán, B. Paull, P.A. Levkin, F. Svec, M. Macka, ISCCE, USA, 2009
  • Enantiomeric gas-chromatographic separations on stationary phases containing multiple chiral selectors (poster presentation) P.A. Levkin, D. Kreidler, H. Czesla, V. Schurig, ISCCE, USA, 2007
  • Polyimide chip with monolithic stationary phases for fast HPLC separations of proteins and peptides (oral presentation) P.A. Levkin, T.R. Stratton, S. Eeltink, R. Brennen, K. Killeen, J.M.J. Fréchet, F. Svec, ISCCE, USA, 2007
  • Chiral selector with ee 99% - a problem for enantioseparation? (poster presentation)
    P.A. Levkin, N.M. Maier, V. Schurig, W. Lindner, ISCD, USA, 2007
  • Quantitative assessment of nonenantioselective versus enantioselective interactions in liquid chromatography on a quinine carbamate anion exchange-type chiral stationary phase (poster presentation) P.A. Levkin, N.M. Maier, V. Schurig, W. Lindner, ISCD, USA, 2007
  • Temperature-induced inversion of the elution order of enantiomers in gas chromatography (oral presentation) P.A. Levkin, A. Levkina, H. Czesla, and V. Schurig, ISCD, USA 2007
  • Practice and theory of enantiomeric separations on mixed chiral stationary phases by gas chromatography. P.A. Levkin, H. Czesla, V. Schurig 29th International symposium on capillary chromatography. Riva del Garda, Italy, 29 May- 2 June, 2006, (oral presentation)
  • Combining  the enantioselectivity of Chirasil- b-Dex and Chirasil-Val-Nova in a mixed binary gas-chromatographic chiral stationary phase. P.A. Levkin, A. Levkina, V. Schurig
    29th International symposium on capillary chromatography. Riva del Garda, Italy, 29 May- 2 June, 2006, (poster presentation)
  • A New Mixed Binary Gas-Chromatographic Chiral Stationary Phase Chirasil- b-DexVal
    P.A. Levkin, V. Schurig. International symposium on hyphenation technics in analytical chemistry, Tuebingen, Germany, 27-29 March, 2006 (poster presentation)
  • Practice and theory of enantiomeric separation on mixed chiral stationary phases by gas chromatography. P.A. Levkin. 16. Doktoranden-Seminar des Arbeitskreises „Separation Science“ der Fachgruppe „Analytische Chemie“ der GDCh. 8-10 January, 2006. (oral presentation)
  • Heptakis(6-O-(N-acetylyl-L-valine-tert-butylamide)-2,3-di-O-methyl)- b-cyclodextrin: a promising chiral solvating agent for NMR determinations of enantiomeric compositions
    G. Uccello-Barretta, S. Nazzi, P. Levkin, V. Schurig. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD45 (poster presentation).
  • Solid-state ESR differentiation between enantiomers vs. racemates. P.A. Levkin, A.I. Kokorin, V. Schurig, R.G. Kostyanovsky. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD36 (poster presentation)
  • Practice and theory of GC separation of enantiomers on mixed chiral stationary phases
    P.A. Levkin, V. Schurig. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD35 (poster presentation)
  • "Racemic compound-conglomerate crystallization and solid phase transformation of the racemic compound into the conglomerate. P.A. Levkin, V. Schurig, E. Schweda, R.G. Kostanovsky. 10th Bremen International Workshop on Industrial Crystallization (BIWIC), Rouen, France, 4-5 September, 2003 (oral presentation)
  • Nanotube formation in crystals of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-diole
    P.A. Levkin, R.G. Kostanovsky. 4th National symposium in organic chemistry, Moscow, July 5-7, 2003 (poster presentation)
  • Temperature-dependent racemate-conglomerate crystallization. P.A. Levkin, R.G. Kostyanovsky. 14th International Symposium on Chirality (ISCD-14). Hamburg, Germany, 9-14 September, 2002, (poster presentation)