Prof. Dr. Pavel Levkin
- [sci.] Professor am Institut für Biologische und Chemische Systeme
- Chemie
- Gruppe: Helmholtz
- Raum: Deutschland, KIT
- Tel.: +49 721 608-29175
- Fax: +49 721 608-23354
- levkin ∂does-not-exist.kit edu
- Forschung
Karlsruhe Institute of Technology (KIT)
Postfach 3640
76021 Karlsruhe
Functional and Stimuli-Responsive Polymer Materials
Junior Research Group of Dr. Pavel Levkin
The goal of our research is to gain better understanding of biological interfaces and to advance our ability to effectively control and direct behavior of eukaryotic cells and bacteria. We are developing biologically active functional polymer surfaces and materials, "smart" switchable polymer surfaces, and gradient surfaces, which we use for investigation of biointerfaces, for studying cell- or bacteria-surface interactions, for studying biofouling and for creating "smart" culture devices. Our motivation is to create polymer films and coatings that will improve performance of existing biomedical devices, implants and cell culture dishes. Our research is very interdisciplinary and we closely collaborate with biologists, microbiologists and physicists.
Publications
Junior Research Group of Dr. Pavel Levkin
PATENTS
- Superhydrophobic and superhydrophilic materials, surfaces and methods. P.A. Levkin, F. Svec, J.M.J. Fréchet. WO/2009/137267; PCT/US2009/041277 (International patent)
PUBLICATIONS
- Visible light initiated polymerization of styrenic monolithic stationary phases using 470 nm light emitting diode arrays. Z. Walsh, P.A. Levkin, V. Jain, B. Paull, F. Svec, and M. Macka J. Sep. Sci. accepted
- Porous polymer coatings: a versatile approach to superhydrophobic surfaces
P.A. Levkin, F. Svec, J.M.J. Fréchet
Adv. Funct. Mater. 19 (2009), 1993-1998 - Monolithic porous polymer stationary phases in polyimide chip for fast HPLC separation of proteins
P.A. Levkin, S. Eeltink, T.R. Stratton, R. Brennen, K. Killeen, F. Svec, J.M.J. Fréchet
Journal of Chromatography A 1200 (2008), 55-61 - Apparent and true enantioselectivity of single- and binary-selector chiral stationary phases in gas chromatography
P.A. Levkin and V. Schurig
Journal of Chromatography A (invited paper in 50th anniversary issue) 1184 (2008), 309-322 - Heptakis[6-O-(n-acetylyl-L-valine-tert-butylamide)-2,3-di-O-methyl]- b-cyclodextrin: a new multifunctional cyclodextrin with improved enantiodiscriminating efficiency towards polar and apolar substrates
G. Uccello-Barretta, S. Nazzi, F. Balzano, P.A. Levkin, V. Schurig, P. Salvadori
European Journal of Organic Chemistry (2007), 3219-3226 - Sterically hindered and completely arrested nitrogen inversion in pyrazolidines
S.V. Usachev, G.A. Nikiforov, K.A. Lyssenko, Y.V. Nelubina, P.A. Levkin, R.G. Kostyanovsky
Tetrahedron-Asymmetry 18 (2007), 1540-1547 - Temperature-induced reversal of elution order of enantiomers in gas chromatography: N-ethoxycarbonyl propyl amides and N-trifluoroacetyl ethyl esters of a-amino acids on Chirasil-Val and Chirasil- b-Dex CSP
P.A. Levkin, A. Levkina, H. Czesla and V. Schurig
Analytical Chemistry, 79 (2007), 4401-4409 - Expanding the enantioselectivity of the gas-chromatographic chiral stationary phase Chirasil-Val-C11 by doping it with octakis(3-O-butanoyl-2,6-di-O-n-pentyl)- g-cyclodextrin
P.A. Levkin, A. Levkina, H. Czesla, S. Nazzi, V. Schurig
Journal of Separation Science, 30, (2007), 98-103 - Combining the enantioselectivities of L-valine diamide and permethylated
b-cyclodextrin in one gas chromatographic chiral stationary phase
P.A. Levkin, A. Levkina, V. Schurig
Analytical Chemistry, 78 (2006), 5143-5148 - Combining the enantioselectivity of a cyclodextrin and a diamide selector in a mixed binary gas-chromatographic chiral stationary phase
P.A. Levkin, A. Ruderisch, V. Schurig
Chirality, 18 (2006), 49-63 - Absolute configuration of Troeger bases: an X-ray diffraction and circular dichroism study
D.A. Lenev, K.A. Lyssenko, D.G. Golovanov, O.R. Malyshev, P.A. Levkin, R.G. Kostyanovsky
Tetrahedron Letters, 47 (2006), 319-321 - Solid-state ESR differentiation between racemate vs. enantiomer
P.A. Levkin, A. I. Kokorin, V. Schurig, R. G. Kostyanovsky
Chirality, 18 (2006) 232-238 - Solid-phase racemic compound-conglomerate transformation of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-dione
P.A. Levkin, E. Schweda, H.-J. Kolb, V. Schurig, R.G. Kostyanovsky
Tetrahedr. Asymm., 15 (2004) 1445-1450 - Temperature-dependent racemic-compound-conglomerate crystallization of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-dione
P. A. Levkin, Y. A. Strelenko, K. A. Lyssenko, V. Schurig, R. G. Kostyanovsky
Tetrahedr. Asymm., 14 (2003) 2059-2066 - A new conglomerate in a series of 2,3:6,7-dibenzobicyclo[3.3.1]nonanes
P. A. Levkin, K. A. Lyssenko, V. Schurig, R. G. Kostyanovsky
Mendeleev Commun., 13 (2003) 106-108 - Ångström-sized pore crystal
R. G. Kostyanovsky, P. A. Levkin, K. A. Lyssenko, Yu. A. Strelenko, D. G. Golovanov
Mendeleev Commun., 12 (2002) 220-222
BOOK CONTRIBUTIONS
“Homo- and heterochirality in crystals“ in Topics in Stereochemistry
P.A. Levkin, V.Yu. Torbeev, D.A. Lenev, R.G. Kostyanovsky
Ed.: F. Toda, John Wiley & Sons Ltd, 25 (2006), 81-134
PRESENTATIONS (oral and poster)
- Use of light emitting diodes in the visible region to initiate polymerisation leading to monolithic stationary phases (poster) Z. Walsh, D. Heger, S. Abele, P. Klán, B. Paull, P.A. Levkin, F. Svec, M. Macka, ISCCE, USA, 2009
- Enantiomeric gas-chromatographic separations on stationary phases containing multiple chiral selectors (poster presentation) P.A. Levkin, D. Kreidler, H. Czesla, V. Schurig, ISCCE, USA, 2007
- Polyimide chip with monolithic stationary phases for fast HPLC separations of proteins and peptides (oral presentation) P.A. Levkin, T.R. Stratton, S. Eeltink, R. Brennen, K. Killeen, J.M.J. Fréchet, F. Svec, ISCCE, USA, 2007
- Chiral selector with ee 99% - a problem for enantioseparation? (poster presentation)
P.A. Levkin, N.M. Maier, V. Schurig, W. Lindner, ISCD, USA, 2007 - Quantitative assessment of nonenantioselective versus enantioselective interactions in liquid chromatography on a quinine carbamate anion exchange-type chiral stationary phase (poster presentation) P.A. Levkin, N.M. Maier, V. Schurig, W. Lindner, ISCD, USA, 2007
- Temperature-induced inversion of the elution order of enantiomers in gas chromatography (oral presentation) P.A. Levkin, A. Levkina, H. Czesla, and V. Schurig, ISCD, USA 2007
- Practice and theory of enantiomeric separations on mixed chiral stationary phases by gas chromatography. P.A. Levkin, H. Czesla, V. Schurig 29th International symposium on capillary chromatography. Riva del Garda, Italy, 29 May- 2 June, 2006, (oral presentation)
- Combining the enantioselectivity of Chirasil- b-Dex and Chirasil-Val-Nova in a mixed binary gas-chromatographic chiral stationary phase. P.A. Levkin, A. Levkina, V. Schurig
29th International symposium on capillary chromatography. Riva del Garda, Italy, 29 May- 2 June, 2006, (poster presentation) - A New Mixed Binary Gas-Chromatographic Chiral Stationary Phase Chirasil- b-DexVal
P.A. Levkin, V. Schurig. International symposium on hyphenation technics in analytical chemistry, Tuebingen, Germany, 27-29 March, 2006 (poster presentation) - Practice and theory of enantiomeric separation on mixed chiral stationary phases by gas chromatography. P.A. Levkin. 16. Doktoranden-Seminar des Arbeitskreises „Separation Science“ der Fachgruppe „Analytische Chemie“ der GDCh. 8-10 January, 2006. (oral presentation)
- Heptakis(6-O-(N-acetylyl-L-valine-tert-butylamide)-2,3-di-O-methyl)- b-cyclodextrin: a promising chiral solvating agent for NMR determinations of enantiomeric compositions
G. Uccello-Barretta, S. Nazzi, P. Levkin, V. Schurig. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD45 (poster presentation). - Solid-state ESR differentiation between enantiomers vs. racemates. P.A. Levkin, A.I. Kokorin, V. Schurig, R.G. Kostyanovsky. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD36 (poster presentation)
- Practice and theory of GC separation of enantiomers on mixed chiral stationary phases
P.A. Levkin, V. Schurig. 17th International Symposium on Chirality (ISCD-17). Parma, Italy, 11-14 September, 2005, PD35 (poster presentation) - "Racemic compound-conglomerate crystallization and solid phase transformation of the racemic compound into the conglomerate. P.A. Levkin, V. Schurig, E. Schweda, R.G. Kostanovsky. 10th Bremen International Workshop on Industrial Crystallization (BIWIC), Rouen, France, 4-5 September, 2003 (oral presentation)
- Nanotube formation in crystals of 2,3:6,7-dibenzobicyclo[3.3.1]nona-2,6-diene-4,8-diole
P.A. Levkin, R.G. Kostanovsky. 4th National symposium in organic chemistry, Moscow, July 5-7, 2003 (poster presentation) - Temperature-dependent racemate-conglomerate crystallization. P.A. Levkin, R.G. Kostyanovsky. 14th International Symposium on Chirality (ISCD-14). Hamburg, Germany, 9-14 September, 2002, (poster presentation)